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The efficacy of mefloquine has not been studied in the in vivo experiments and clinical trials involving COVID-19 patients. The study was aimed to assess the effects of mefloquine on the SARS-CoV-2 accumulation in the lungs of infected animals and to study the efficacy and safety of mefloquine compared to hydroxychloroquine in patients with COVID-19. During the experiment, a total of 96 Syrian hamsters were infected with SARS-CoV-2. Accumulation of the virus in lungs was compared in the groups of animals treated with mefloquine and ribavirin and in the control group. During the clinical trial, the mefloquine and hydroxychloroquine safety and efficacy in patients with mild and moderate COVID-19 (172 individuals) was assessed based on the symptom changes over time and the computed tomography results. The experiment showed that the SARS-CoV-2 accumulation in the lungs of Syrian hamsters 6 days after infection and mefloquine treatment was 2.2 +/- 0.18 lg PFU/g, which was lower (p < 0.05) than in the control group (3.5 +/- 0.21 lg PFU/g) and ribavirin group (5.2 +/- 0.05 lg PFU/g). During the clinical trial, it was found that 50.0% of patients in the mefloquine group and 32.4% in the hydroxychloroquine group (p < 0.05) developed a mild disease, and the completely resolved respiratory failure was registered in 76.5% and 44.6%, respectively (p < 0.001). Adverse events were observed in 86.7 % and 77% of patients in the mefloquine and hydroxychloroquine groups, respectively (p > 0.05). Thus, during the experiment, mefloquine contributed to the faster virus titer reduction in the lungs. During the clinical trial, the mefloquine efficacy was non-inferiority or, based on a number of indicators, higher compared to hydroxychloroquine, with comparable safety.Copyright © Extreme Medicine.All right reserved.
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Remdesivir (GS-5734) is a new direct-acting antiviral drug in the nucleotide analogue class with antiviral activity against SARS-CoV-2 and the ability to inhibit RNA-dependent RNA polymerase. Preliminary results from phase III randomized clinical trials of remdesivir are inconsistent. Understanding the fact of the limited world experience with the use of remdesivir in COVID-19 required further study of its efficacy and safety in real clinical practice. The aim of the study is to evaluate the efficacy and safety of remdesivir in the treatment of patients with COVID-19. Material and methods. The study included 1422 patients with a novel coronavirus infection (COVID-19) who received remdesivir as part of complex therapy in a hospital setting at medical organizations of the Moscow public health system. Additionally, standard therapy was carried out, regulated by the Interim Guidelines "Prevention, Diagnosis and Treatment of Novel Coronavirus Infection (COVID-19)" of the Ministry of Healthcare of the Russian Federation, the current version. The efficacy of the drug was assessed based on primary and secondary efficacy points. Primary variable: 1) cumulative incidence of clinical outcomes in patients with COVID-19 treated with remdesivir as part of complex therapy;2) median time to clinical improvement according to the World Health Organization ordinal categorical scale (under clinical improvement, the patient is assumed to move >2 categories towards improvement in clinical condition). Secondary variables: 1) median time to achieve <2 NEWS scores lasting at least 24 hours or hospital discharge;2) mortality from all causes;3) duration of fever (>38 degreeC), days;4) duration of hospitalization, days;5) time to achieve elimination of the pathogen from the upper respiratory tract (no SARS-CoV-2 RNA), days. The safety of remdesivir was assessed based on the registration of adverse events using the method of spontaneous reports. Results. The analysis of clinical outcomes of treatment showed that 1195 (84.1%) patients recovered, death from all causes occurred in 227 (15.9%) patients. The median improvement in clinical status on the World Health Organization ordinal categorical scale was 6 days. The median time to reach a NEWS score of <2, lasting at least 24 hours, or hospital discharge was 4 days. The median duration of fever was 3 days from the start of remdesivir administration. The median length of hospital stays for patients included in the Register was 9 days. Adverse reactions associated with the use of remdesivir were recorded in 11 (0.7%) patients. Serious adverse reactions were not registered. During hospitalization, all adverse reactions were resolved. Conclusion. A retrospective analysis of data from the Registry of 1422 patients with COVID-19 who received remdesivir as part of complex therapy in medical organizations of the state healthcare system of Moscow in routine clinical practice showed clinical efficacy and a favorable safety profile of remdesivir (Remdeform, lyophilizate for solution for intravenous administration 100 mg, manufactured by JSC Pharmasyntez, Russia). The data obtained are consistent with previous randomized clinical trials of remdesivir and allow us to recommend its further use in patients with COVID-19 as part of complex therapy.Copyright © The Author(s), 2022.
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Purpose: To explore how motivational interviewing (MI) training might benefit the practice of COVID-19 contact tracers. Design/methodology/approach: Following co-production of a MI training package, with a United Kingdom (UK) track and trace organisation, training was delivered virtually to 101 volunteer participants involved in contact tracing. Data were captured via an online survey, incorporating questions from recognised measures of occupational self-efficacy and workplace wellbeing, prior to the training. Open data fields were used to gather feedback about participants' reasons for attending, and views about the training afterwards. Finding(s): Although the contact tracers reported high occupational self-efficacy and workplace wellbeing, both quantitative and qualitative data suggested participants saw practitioner value and utility in MI. Research limitations/implications: The sample was self-selecting and typically involved contact tracers from UK local authorities. The study did not measure impact on compliance with self-isolation guidance and/or providing details of contacts, and larger-scale research would be needed to establish this. This was not a pre-post-test evaluation study, and measures of occupational self-efficacy and workplace wellbeing were gathered to give insight into the sample and to test the feasibility of using this survey for a future large-scale study. The research was conducted during the height of the pandemic. While UK COVID-19 contact tracing services have since been reduced, there are potential implications for infection control more generally. Practical implications: MI is potentially a useful approach for enhancing contact tracing practice. However, implementation factors should be carefully considered, to ensure effective and sustainable practice. Social implications: Improved practice in contact tracing could have potential benefits in infection control, through improving compliance with central guidance, although this requires more widespread investigation. Originality/value: This is the first empirical study to investigate how MI training could benefit COVID-19 contact tracing practice.Copyright © 2023, Emerald Publishing Limited.
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Background: Inflammatory acute respiratory syndrome (SARS) is caused by the COV-2 virus. Neutrophils have been implicated in the pathophysiology of the COVID-19 pandemic since its inception, particularly in individuals with advanced disease. This is confirmed by a large number of studies. Method(s): The study included 200 patients, of whom 100 were in the critical group (group 1) and 100 were in the non-critical group (group 2). White blood cell (WBC) percentage, neutrophil count, albumin, and demographic information were recorded. Neutrophil percentage x 100 /Albumin (g/dl) was used to construct the neutrophil count to albumin ratio (NPAR). To determine whether the measure may be utilized as a predictor for mortality, the NPAR is then compared between groups 1 and 2, as well as between discharge and mortality groups. Result(s): Age and gender had no statistically significant differences in either group. There were no significant variations in the median (IQR) values of neutrophil count (89 vs 91.25), WBC (15.65 vs 14.9), and NPAR (41.3 vs 43.7) between the two groups. Significant differences in albumin (3.330.521 vs. 3.10.51) were identified between the critical and non-critical groups. Conclusion(s): According to our research, the COVID-19 patients' NPAR is a poor predictor of mortality. More study is still required to verify and elucidate the clinical implications of these findings.Copyright © 2023 Lahore Medical And Dental College. All rights reserved.
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Mechanical ventilators are advanced life-supporting machines in this century. The ventilator needs to be safe, flexible, and easy for competent clinicians to use. Since ventilators supply the patient with gas, they need pneumatic components to be present. First technology ventilators were typically powered by pneumatic energy. Gas pressure is used to power ventilators as well as ventilate patients. Nowadays, ventilators are operated electronically with the useful microprocessor tool. This proposal aims to design a simple portable mechanical ventilator that includes measuring some important physiological variables such as respiratory rate, heart rate, and O2 saturation, which can be utilized in hospital and at home. The proposed system includes Arduino, Raspberry pi4, touch screen, and graphical user interface. This study showed a significant individual performance for measuring some important parameters such as flow rate, tidal volume, and minute ventilation. The accuracy of measuring the flow rate was 72%. The Cohen's kappa (CK) was estimated to be 0.61. The accuracy of calculated the tidal volume was estimated at 83% with 0.80 CK. The accuracy of measuring the O2 saturation was estimated at 99% with 0.99 CK. The advantages of the proposed design are cost-effective, safe, flexible, and easy to use. Also, this system is smart and can control its transactions, so it can be used at home without the need for professional help. The operating parameters can also be set by the user with a simple user interface.Copyright © 2022 by ASME.
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Background: In the past 20 years, humanity, particularly in the Middle East, has experienced three outbreaks of coronavirus disease, restricting our ordinary activities. In addition to the growing risk of chemical, biological, radiological, nuclear, and explosive incidents, discussing an alternative to the usual refresher or first-time face-to-face disaster preparedness education is necessary. This study aimed to evaluate the participants' educational outcomes following their participation in the "HazMat/CBRNe in the context of mass gatherings"online pilot workshop, which used PowerPoint presentations, a remotely facilitated tabletop exercise, and videos. Methods and Analysis: This was a retrospective quantitative analysis study based on the participants' pre- and post-workshop session 1 multiple choice assessment scores and their evaluation results. Result(s): Although it was based on a small number of participants, the implemented workshop helped accomplish the participants' educational outcomes. Conclusion(s): This study demonstrated that this online workshop helped fulfil the participants' educational needs and familiarize them with the concept of readiness and preparedness for CBRNe threats in mass gatherings;hence, it should be conducted again for other participants. The increasing worldwide use of CBRN agents in industries and bioterrorism heightens the need to ensure appropriate healthcare workers' readiness through practical, innovative continuous professional development tools in times of pandemics.Copyright © 2022 Farhat, Laughton, Joseph, Abougalala, Dhiab, Alinier, licensee HBKU Press.
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Background: It is very important to increase awareness and understanding of oral manifestations of post COVID-19 disease among dentists which can happen by continuing education and training for dentists to recognize and manage oral manifestations of post COVID-19 disease. Aims & objectives: The aim of this is to aware dentists regarding oral manifestation of covid 19 disease. The objectives of study were to assess the level of awareness, understanding and factors influencing awareness among dentists regarding oral manifestations of post COVID-19 disease. Evaluate the of oral manifestations of post COVID-19 among dentists in central India. Methodology: A cross-sectional, questionnaire-based study was carried out among COVID-19 recovered patients. A sample of 100 subjects, diagnosed as mild and moderate cases of COVID-19 disease were selected based on inclusion and exclusion criteria. A well-structured questionnaire composed of total 21 Closed ended questions was send to sunjects. Result(s): The study comprised an almost equal number of male (54%) and female (48%) participants and among them, 47% belong to the health professional group. A total of 56% of subjects were aged above 35 years and 47% below 35 years. Xerostomia, frequent aphthous ulcers, swallowing difficulty, and burning mouth were the most frequently encountered symptoms in study subjects during the disease and post recovery. Conclusion(s): In the present study, dentists were found to have good knowledge toward novel corona virus disease with optimum preparedness level for dental practice modification. Dental fraternity is further advised to follow the standard guidelines overcoming this pandemic.Copyright © 2022 Authors. All rights reserved.
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Prevention is better than cure This covid-19 pandemic has made many changes in everyone's life, in this pandemic WHO focuses on the safety of healthcare workers and Safety ofpatients, WHO set COVID-19 protocols. Aim(s): Assessment of educational intervention on knowledge regarding World Health Organization covid-19 protocols during delivery among staff nurses. Methodology: The present study is evaluative study with methodological research design. A total of 60 samples were selected for the study by using the non -probability purposive sampling technique based on the selection criteria. The reliability was done by using the test re-test method for structured questionnaire. Data were analysed by using descriptive and inferential statistics. Result(s): In pre-test, 43.3% of the staff nurses had average knowledge (Score 4 to 6), 55% of them had good knowledge (Score 7 to 9) and 1.7% of them had excellent knowledge (Score 10) regarding WHO covid 19 protocols.In post-test, 18.3% of them had good knowledge (Score 7 to 9) and 81.7% of them had excellent knowledge (Score 10) regarding WHO covid 19 protocols. This indicates that the knowledge among the staff nurses regarding WHO covid 19 protocols had improved remarkably after the health teaching. Researcher had applied paired t-test for the effect of health teaching on knowledge regarding WHO covid 19 protocols. Average knowledge scorein pre-test was 6.8;which increased to 9.8 in post-test. T-value for this test was 14.08 with 59degrees of freedom. Corresponding p-value was small (less than 0.05), the null hypothesis is rejected. It is evident that the knowledge among the staff nurses regarding WHO covid 19protocols had improved significantly after health teaching. Conclusion(s): there is a significant gap in the knowledge score WHO COVID-19 Protocol among labour room nurses, and hence there is need for a WHO COVID-19 Protocol for the improvement of knowledge.Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.
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The proceedings contain 7 papers. The topics discussed include: pediatric burn care: how burn camps survived and thrived during the coronavirus pandemic;a retrospective chart review to determine hypophosphatemia incidence and phosphorus supplementation requirements in patients with severe thermal cutaneous injuries receiving high-volume hemofiltration;setting the standard: using the aba burn registry to benchmark risk adjusted mortality;burn injury from smoking electronic cigarettes while on supplemental oxygen;focused wound care handoff improves burn center physician-nursing communication and wound care education;modified frailty index is an independent predictor of death in the burn population: a secondary analysis of the transfusion requirement in burn care evaluation (TRIBE) study;and topical hemostatic agents in burn surgery: a systematic review.
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Background and Aims: Data usage is essential in diabetescare, but facilitating HCP's to provide patients with timely and regular (eHealth) insights is complex. We developed a brand-agnostic CE-marked, population management eHealthapplication, CloudCare, providing a 'closed-data-loop' between patients and HCP's. Method(s): It uploads insulin- and glucosedevice-data from all platforms/brands both by manual uploads (patient) or automated uploading. The system is used 8 years in Diabeter and resulted in more than 10.000 'dataloops'/year mainly from manual uploads by the patient. We analysed outcomedata and visit/contactdata. Result(s): The system helped to improve outcomes despite COVID-19, implementation of technologie and significant growth and helpt switching to remote care (Table) with 50% of children and 57% of adults reaching HbA1c below 7.5% (58mmol/mol) in 2021. To accommodate increasing data usage, automatic data-uploads and translate data to insights, we further developed the system to tracks data and offer decision-support. This allows triage-driven risk stratification of clinically relevant cases, allowing timely interventions. Data-use, frequencies of planned contacts as well as 'snoozing' periods are defined in a service level agreement with patients. Automated input from 2505 780G- and IS-CGM users, creates approx. 2200 daily datasets. Automated triaging reduces this to a workload to 20-65 relevant cases per day which are reviewed and forwarded to HCPs. Settings for triaging are flexible and temporary 'snoozing' is possible. Conclusion(s): Further evaluation studies includes clinical impact and impact on the organization including costs. We will seek to include additional clinics in the evaluation. Solutions such as CloudCare will help to integrate modern diabetes-treatment and improve outcomes.
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Objective To effectively express the receptor binding domain (RBD) of SARS-CoV-2 spike protein in Pichia pastoris and to evaluate its immunogenicity. Methods The gene encoding the RBD protein was synthesized and cloned into the pPICZalphaA plasmid. After linearization, the plasmid was transferred and integrated into the genome of Pichia pastoris. The expressed RBD protein in culture supernatant was analyzed by Western blot and Biolayer interferometry. After screening, a single clone expressing the RBD protein was selected. The high-level expression of RBD protein was achieved by optimizing the fermentation process, including the salt concentration adjusting of the medium and induction condition optimization (pH, temperature and duration) . The immunogenicity of the expressed RBD protein was evaluated in a mouse model. Results A single clone with a high expression level of RBD protein was obtained and named RBD-X33. The expression level of RBD protein in the fermentation supernatant reached up to 240 mg / L after optimization of the induction condition (HBSM medium, pH = 6. 5 +/- 0. 3, 22 and 120 h) . In the mouse experiment, the recombinant RBD protein was formulated with Alum + CpG dual adjuvant and injected into mice. The binding IgG antibody levels were up to 2. 7 x 106 tested by ELISA and the neutralizing antibody levels were up to 726. 8 tested by live virus neutralizing antibody assay (prototype) . Conclusions The RBD protein could be efficiently expressed in Pichia pastoris and induce stronger immune response in animals. This study suggested that the recombinant SARS-CoV-2 RBD protein expressed in Pichia pastoris could serve as a candidate antigen in the development of SARS-CoV-2 vaccine.Copyright © 2022 Society of Microbiology and Immunology. All rights reserved.
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In this study Evaluation of the Prevalence of Heart Problems in Patients with Covid-19 with High Blood Pressure and Diabetes in Patients Admitted to ICU was investigated. Due to the small number of some underlying diseases such as asthma, acute respiratory disease, liver, kidney and cancer, these diseases were merged together and entered as a variable. According to the results of univariate logistic regression, body mass index, diabetes and underlying diseases were related to contracting the Covid-19 disease, so that an increase of one unit of body mass index was 4% and diabetes and underlying diseases also had a 41% chance. It increased the incidence of Covid-19. All variables were entered into the multivariable regression model by enter method to calculate their simultaneous effect. Collinearity between quantitative variables was checked and rejected. After entering the variables into the multivariable logistic regression and observing the effect of each variable in the presence of other variables, almost the same results as the univariate regression were obtained. The results of the present study showed that the risk of hospitalization due to Covid-19 disease is significantly related to male gender and old age, because increasing age leads to defects in the body's immune system's response to pathogens and increases the rate of hospitalization. Also, the current research showed that blacks, obese people and smokers, as well as people with underlying diseases such as diabetes, cardiovascular diseases, kidney and high blood pressure, have the highest number of hospitalizations due to Covid-19. They are because the efficiency of the immune system response in these people is low, so it leads to severe type of disease and hospitalization. Many signs and symptoms in the elderly appear atypical or unusual. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.
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Background: Studies show 1:1 in-person Alexander technique (AT) sessions can reduce anxiety and musculoskeletal pain with long-term benefits [1-4]. Care partners (CP) often experience role engulfment and loss of self [5]. AT is an embodied approach to choose functional patterns that transform disruptive stress reactions to adaptive responses, increasing confidence, self-control, and self-awareness. Previous in-person group course results from 71 Parkinson's CP showed promise with benefits retained at 12 months. COVID-19 provided an opportunity to test synchronous online AT-based courses for CP of people living with dementia. Method(s): Design: Controlled feasibility trial. AT group: 14 participants (12F/2M) from 9 states;mean age 68;72% provided 41+ hrs/wk care for family member with dementia;13 lived with care-receiver. Control group: 9 participants (8F/1M) from 4 states;mean age 63;67% provided 41+ hrs/wk care;6 lived with family care-receiver. AT groups met 90 min/week x 10wks. Intervention(s): Delivered in-home via Zoom. Embodied self-management strategies included intentional strategies to interrupt automatic reactions and affirm centrality of the self, taught via verbal and visual instruction, activities, anatomical models/images, and demonstration videos. AT principles were embedded in everyday activities (gait, sit-to-stand, IADLs, etc.). Outcome Measures: Self-report, executive function, anonymous evaluations, interviews. Result(s): 70% retention, 87% attendance. AT group improved executive function (Digit Span p =.003;Stroop p =.05);control group did not. AT group reported increased self-efficacy (caregiver scale p =.08);and reduced fear (p =.004);control group did not. On 0-10 scale, mean rating was >9 for novelty of ideas, practical tools for physical self-management, and would recommend to a friend;and >8 for enjoyment of group interaction, practical tools for self-management of emotions and reactions, and prevention of pain;7.9 for feeling better prepared for CP daily challenges. Six-month follow-up is underway. Conclusion(s): Alexander technique shows promise as a long-term self-management approach to reduce loss-of-self in CP of people living with cognitive decline. Group classes can provide cost-effective delivery with social benefits. Online classes can increase accessibility. A full-scale study is merited. 1.Little (2008) 2.MacPherson (2015) 3.Klein (2014) 4.Stallibrass (2002) 5.Skaff, Pearlin (1992). Copyright © 2022 the Alzheimer's Association.
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Objective: The purpose of this study is to provide an overview of apps to help control the spread of Covid-19 in Germany and rate them according to standardized instruments. Materials and methods: The Apple App Store and Google Play Store were systematically searched to identify apps dealing with Covid-19 in Germany. The German Mobile App Rating Scale (MARS-G) was used to independently assess app quality by 2 trained reviewers. Results: Overall, the quality of the 6 rated apps was good with a mean score of 4.15 (3.88-4.34). The best-rated apps were NINA app (4.34) and Corona Health App (4.29). The best-rated sections were functionality (4.40), aesthetic (4.25), and information (4.25). In contrast, the worst-rated section was engagement (3.63). Even though some of the apps were used by more people than others, there was no correlation between the MARS-G rating and app store rating. In addition, the MARS-G proved to be effective even with rating apps, which have different goals and methods to achieve them. Conclusions: To our knowledge, this is the first study that identified and evaluated German Covid-19 mobile health apps available in the German app stores. The review shows that despite the excellent quality in aspects like information and functionality, there is still a gap in the engagement section. To motivate more people to use the Covid-19 apps, new ideas are needed, besides more information and education about the functionality of the apps, to gain trust in app developers and raise the number of downloads.
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Aim: This study aimed to evaluate chemokine receptor 5 delta 32 (CCR5-δ32) mutation and HIV-1 surveillance drug-resistance mutations (SDRMs) in peripheral blood mononuclear cells of long-term non progressors (LTNPs) of HIV-1-infected individuals. Materials & methods: This research was performed on 197 treatment-naive HIV-1-infected patients. After follow-up, it was determined that 15 (7.6%) of these people were LTNPs. The PCR assay was performed to identify the CCR5 genotype and HIV-1 SDRMs. Results: One (6.7%) of the LTNPs was heterozygous (wt/δ32) for the CCR5 delta 32 (CCR5δ32). However, none of the individuals was homozygous for this mutation (δ32/δ32). Moreover, none of the LTNPs showed HIV-1 SDRMs. The CRF35-AD subtype was the most dominant subtype, with a percentage of 93.3%. Conclusion: Iranian elite controllers are negative for CCR5-delta 32 homozygous genotype and drug resistance against antiretroviral drugs.
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BACKGROUND: The SARS-CoV-2 (COVID-19) pandemic may accelerate the adoption of digital, decentralized clinical trials. Conceptual recommendations for digitalized and remote clinical studies and technology are available to enable digitalization. Fully remote studies may break down some of the participation barriers in traditional trials. However, they add logistical complexity and offer fewer opportunities to intervene following a technical failure or adverse event. OBJECTIVE: Our group designed an end-to-end digitalized clinical study protocol, using the Food and Drug Administration (FDA)-cleared Current Health (CH) remote monitoring platform to collect symptoms and continuous physiological data of individuals recently infected with COVID-19 in the community. The purpose of this work is to provide a detailed example of an end-to-end digitalized protocol implementation based on conceptual recommendations by describing the study setup in detail, evaluating its performance, and identifying points of success and failure. METHODS: Primary recruitment was via social media and word of mouth. Informed consent was obtained during a virtual appointment, and the CH-monitoring kit was shipped directly to the participants. The wearable continuously recorded pulse rate (PR), respiratory rate (RR), oxygen saturation (SpO2), skin temperature, and step count, while a tablet administered symptom surveys. Data were transmitted in real time to the CH cloud-based platform and displayed in the web-based dashboard, with alerts to the study team if the wearable was not charged or worn. The study duration was up to 30 days. The time to recruit, screen, consent, set up equipment, and collect data was quantified, and advertising engagement was tracked with a web analytics service. RESULTS: Of 13 different study advertisements, 5 (38.5%) were live on social media at any one time. In total, 38 eligibility forms were completed, and 19 (50%) respondents met the eligibility criteria. Of these, 9 (47.4%) were contactable and 8 (88.9%) provided informed consent. Deployment times ranged from 22 to 110 hours, and participants set up the equipment and started transmitting vital signs within 7.6 (IQR 6.3-10) hours of delivery. The mean wearable adherence was 70% (SD 19%), and the mean daily survey adherence was 88% (SD 21%) for the 8 participants. Vital signs were in normal ranges during study participation, and symptoms decreased over time. CONCLUSIONS: Evaluation of clinical study implementation is important to capture what works and what might need to be modified. A well-calibrated approach to online advertising and enrollment can remove barriers to recruitment and lower costs but remains the most challenging part of research. Equipment was effectively and promptly shipped to participants and removed the risk of illness transmission associated with in-person encounters during a pandemic. Wearable technology incorporating continuous, clinical-grade monitoring offered an unprecedented level of detail and ecological validity. However, study planning, relationship building, and troubleshooting are more complex in the remote setting. The relevance of a study to potential participants remains key to its success.
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The Indonesian Government has launched PeduliLindungi (PL) mobile apps as a COVID-19 preventive tool. This study aimed to describe the PL utilization and determine the factors influencing its successful use among college students. This study used a cross-sectional design and a total population sampling at a university in the Special Capital Region of Jakarta, Indonesia. The Delone and Mclean Information System Success Model was adopted to measure the use of the apps. The Spearman's rank correlation test was performed to determine the relationship between two variables. Furthermore, 354 respondents participated in this study. The respondents used the apps mostly to display the vaccination certificate and check in/out from public facilities. The overall user satisfaction value towards the application was 3.83 +/- 0.76. The system quality (rho = 0.621, p-value<0.001) and information quality (rho = 0.626, p-value<0.001) were associated with the user satisfaction while the user satisfaction (rho = 0.471, p-value<0.001), was correlated to the perceived benefit. In brief, perceived benefit was positively correlated with the user's satisfaction, whereas user satisfaction was positively correlated with self-efficacy, system quality, and information quality.